Lusi, Putri Dwita dan Ema, Dewanti dan Vera, Ladeska dan Sediarso, Sediarso dan Adnan, Adnan dan Rahma, Wulan Sari (2018) Neuropharmacological activity of nut grass (Cyperus Rotundus L.) rhizome fraction. Pharmaciana, 8 (2). pp. 217-224. ISSN 2088 4559
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Abstract
The flavonoids content of Cyperus rotundus rhizomes is presumed to show activities on a central nervous system involving GABAergik. This research aimed to further investigate the neuropharmacological properties of Cyperus rotundus rhizomes fraction by measuring their hypnotic-sedative and anticonvulsant activities. The exploratory behavior test was performed using the hole-board method, while the motor coordination was assessed using the rotarod test. The results showed that the 70% ethanol fraction of Cyperus rotundus rhizome exhibited significant neuropharmacological activities (p < 0.05). Among the three fractions tested in this research (i.e., ethanol, ethyl acetate, and n-hexane), the ethanol fraction showed the best hypnotic-sedative and anticonvulsant activities. The ethanol fraction of Cyperus rotundus rhizome could shorten the duration of HLE equal to sodium valproate and potentiate phenobarbital-induced sleep by reducing the onset and prolonging the duration of sleep. The highest dose of the 70% ethanol fraction of Cyperus rotundus rhizome (356.7 mg/kg) displayed the best anxiolytic activity, resembling that of diazepam (p>0.05). In conclusion, Cyperus rotundus rhizome appeared as potent neuropharmacological drug candidate with abilities comparable to synthetic drugs.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Depositing User: | admin repository uhamka |
| Date Deposited: | 09 Jan 2019 04:14 |
| Last Modified: | 09 Jan 2019 04:14 |
| URI: | http://repository.uhamka.ac.id/id/eprint/602 |
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