Neuropharmacological activity of nut grass (Cyperus Rotundus L.) rhizome fraction

Lusi, Putri DwitadanEma, DewantidanVera, LadeskadanSediarso, SediarsodanAdnan, AdnandanRahma, Wulan Sari (2018) Neuropharmacological activity of nut grass (Cyperus Rotundus L.) rhizome fraction. Pharmaciana, 8 (2). pp. 217-224. ISSN 2088 4559

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Abstract

The flavonoids content of Cyperus rotundus rhizomes is presumed to show activities on a central nervous system involving GABAergik. This research aimed to further investigate the neuropharmacological properties of Cyperus rotundus rhizomes fraction by measuring their hypnotic-sedative and anticonvulsant activities. The exploratory behavior test was performed using the hole-board method, while the motor coordination was assessed using the rotarod test. The results showed that the 70% ethanol fraction of Cyperus rotundus rhizome exhibited significant neuropharmacological activities (p < 0.05). Among the three fractions tested in this research (i.e., ethanol, ethyl acetate, and n-hexane), the ethanol fraction showed the best hypnotic-sedative and anticonvulsant activities. The ethanol fraction of Cyperus rotundus rhizome could shorten the duration of HLE equal to sodium valproate and potentiate phenobarbital-induced sleep by reducing the onset and prolonging the duration of sleep. The highest dose of the 70% ethanol fraction of Cyperus rotundus rhizome (356.7 mg/kg) displayed the best anxiolytic activity, resembling that of diazepam (p>0.05). In conclusion, Cyperus rotundus rhizome appeared as potent neuropharmacological drug candidate with abilities comparable to synthetic drugs.

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Depositing User: admin repository uhamka
Date Deposited: 09 Jan 2019 04:14
Last Modified: 09 Jan 2019 04:14
URI: http://repository.uhamka.ac.id/id/eprint/602

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