Microwave Assisted Synthesis of p-Methoxycinnamamides and p-Methoxy--nitrostyrenes from Ethyl p-methoxycinnamate and Screening their Anti-inflammatory Activity

Supandi Supandi, Supandi Microwave Assisted Synthesis of p-Methoxycinnamamides and p-Methoxy--nitrostyrenes from Ethyl p-methoxycinnamate and Screening their Anti-inflammatory Activity. Natural Product Communications, 12 (8). pp. 1265-1268. ISSN 1555-9475

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Abstract

A new modification reaction of ethyl p-methoxycinnamate (1) to afford a series of p-methoxycinnamamide and p-methoxy--nitrostyrene has been developed by using the assistance of the unmodified microwave oven. The synthesized compounds were characterized by using various spectroscopic techniques and furthermore screened for their anti-inflammatory activity by using anti-denaturation of heat bovine serum albumin (BSA) method. The result of bioassay indicated that p-methoxycinnamamide derivatives and p-methoxy--nitrostyrenes showed interesting anti-inflammatory activity.

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Depositing User: admin repository uhamka
Date Deposited: 16 Oct 2018 03:30
Last Modified: 16 Oct 2018 03:30
URI: http://repository.uhamka.ac.id/id/eprint/577

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