SUBCHRONIC TOXICITY TEST OF COMBINATION OF GINGER (Zingiber officinale Rose.) EXTRACT AND ZINC ON SWISS WEBSTER MICE

Hadi Sunaryo, Hadi and Siska, Siska and Dwitiyanti, Dwitiyanti and Rizky Arcinthya Rachmania, Rizky and Roja Fathul Mubdy, Roja (2015) SUBCHRONIC TOXICITY TEST OF COMBINATION OF GINGER (Zingiber officinale Rose.) EXTRACT AND ZINC ON SWISS WEBSTER MICE. Proceeding International Seminar. ISBN 978-602-71959-0-5

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Abstract

The combination of ginger (Zingiber officinale Rose.,) extract and zinc has the effect of lowering levels of glucose, triglycerides, cholesterol and anti-oxidants. This study aimed to determine the safety administration of combination ginger extract and zinc, through subchronic toxicity test. Parameters measured were body weight, liver and kidney histopathology. SGOT. and SGPT The study used a sample of 20 male mice, divided into one control group and one treatment group. The extract was given orally through a sonde for 75 days. The treatment group were given a combination of ginger extract and zinc (ginger 30mg / 20g BW + zinc 0.4mg / 20g BW ) and control group was given a water. After 75 days of treatment sample blood the heart and then checked SGOT and SGPT. Collected statistical from result with the method of independent samples T test showed no significant difference between the levels of SGOT ang SGPT control group to the treatment group. It can be concluded combination ginger extract and zinc did not show any toxic effects in subchronic and did not cause toxicity and damage to vital organs, such as liver and kidney.

Item Type: Book
Subjects: Q Science > Q Science (General)
Depositing User: admin repository uhamka
Date Deposited: 28 May 2018 07:17
Last Modified: 10 Jul 2018 04:27
URI: http://repository.uhamka.ac.id/id/eprint/483

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