COMBINATION OF GINGER EXTRACT (Zingiber officinale Roscoe) AND ZINC AS METABOLIC SYNDROME IN HIGH CHOLESTEROL DIET DIABETIC MICE

Hadi Sunaryo, Hadi and Siska, Siska and Dwitiyanti, Dwitiyanti and Rizky Arcinthya Rachniania, Rizky COMBINATION OF GINGER EXTRACT (Zingiber officinale Roscoe) AND ZINC AS METABOLIC SYNDROME IN HIGH CHOLESTEROL DIET DIABETIC MICE. In: METABOLIC SYNDROME: NOW AND FUTURE TREND. Faculty Of Pharmacy and science, pp. 5-11. ISBN 978-602-71959-2-9

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Abstract

Metabolic syndrome including the presence of obesity, insulin resistance and dyslipidemia that predisposes type 2 diabetes. The puipose of this study to prove the effectiveness of the combination of the ethanol extract of ginger (Zingiber officinale Roscoe) with Zinc (Zn) as a hypolipidemia, and hypoglycemia through the measurement of oxidized LDL, total cholesterol, triglycerides in diabetic mice fed high-cholesterol diet. This study used 54 male mice were divided into 9 groups: normal control group, negative control, positive control, ginger extract (ZO) group dose of 37.5 mg/kg, Zn 20 mg/kg and five groups with a test dose variation that ginger dose 1 (37.5 mg/kg) + Zn 20 mg/kg, ginger dose 2 (75 mg/kg) + Zn 20 mg/kg, ginger dose 3(150 mg/kg) + Zn 20 mg/kg of each test group given the extract for 14 days. Animal models used were mice induced by streptozotocin (STZ) and feed hypercholesterolemia. The results obtained from this study, combined with ginger extract 75 mg/kg and zinc 20 mg/kg can lower blood glucose levels by 39.87 %, comparable to metformin (p > 0.05). The combination of ginger extract 75 mg/kg with zinc 20 mg/kg can lower total cholesterol 65.88%, LDL cholesterol 74.62% and triglyceride levels 55.41%, comparable to atorvastatin (p > 0.05). The addition of Zn to ginger (ZO) extract can increase hypolipidemia activity and hypoglycemic activity of ginger extract.

Item Type: Book Section
Subjects: Q Science > Q Science (General)
Depositing User: admin repository uhamka
Date Deposited: 28 May 2018 07:08
Last Modified: 10 Jul 2018 04:31
URI: http://repository.uhamka.ac.id/id/eprint/482

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