Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L.

Siska, Siska (2019) Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L. Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L., 66 (2). pp. 26-31. ISSN 1338-6786

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Abstract

Trees and shrubs of the genus Cordia are widely distributed in the warmer regions, including Indonesia. The aim of this study was to evaluate the analgesic and anti-inflammatory properties of the ethanolic extract of plant leaves in Wistar albino rats. The analgesic activity was evaluated using the hot plate method and acetic acid-induced writhing, and the anti-inflammatory activity was determined using carrageenan-induced paw oedema. The results showed that the Cordia sebestena ethanol extract (100, 200 and 400 mg/kg) exhibited significant analgesic effects in a dose-dependent manner in the two pain models tested. The extract also exhibited significant anti-inflammatory effects in the carrageenan-induced inflammation test. The data obtained support the traditional folklore therapeutic claim about its analgesic and anti-inflammatory properties. Nonetheless, further scientific investigation is required to establish its analgesic and anti-inflammatory properties in other experimental models and clinical settings.

Item Type: Article
Subjects: Q Science > Q Science (General)
Divisions: Fakultas Farmasi dan Sains
Depositing User: Supandi Supandi
Date Deposited: 15 Nov 2020 14:20
Last Modified: 06 Jan 2021 08:06
URI: http://repository.uhamka.ac.id/id/eprint/4703

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