Siska, Siska (2019) Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L. Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L., 66 (2). pp. 26-31. ISSN 1338-6786
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Abstract
Trees and shrubs of the genus Cordia are widely distributed in the warmer regions, including Indonesia. The aim of this study
was to evaluate the analgesic and anti-inflammatory properties of the ethanolic extract of plant leaves in Wistar albino rats.
The analgesic activity was evaluated using the hot plate method and acetic acid-induced writhing, and the anti-inflammatory
activity was determined using carrageenan-induced paw oedema. The results showed that the Cordia sebestena ethanol extract
(100, 200 and 400 mg/kg) exhibited significant analgesic effects in a dose-dependent manner in the two pain models tested. The
extract also exhibited significant anti-inflammatory effects in the carrageenan-induced inflammation test. The data obtained
support the traditional folklore therapeutic claim about its analgesic and anti-inflammatory properties. Nonetheless, further
scientific investigation is required to establish its analgesic and anti-inflammatory properties in other experimental models and
clinical settings.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Fakultas Farmasi dan Sains |
| Depositing User: | Supandi Supandi |
| Date Deposited: | 15 Nov 2020 14:20 |
| Last Modified: | 28 Nov 2021 08:30 |
| URI: | http://repository.uhamka.ac.id/id/eprint/4703 |
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