COMPARISON OF MANNITOL, LACTOSE, AND SUCROSE AS FILLER ORALLY DISINTEGRATING TABLETS DIMENHYDRINAT

Fahjar Prisiska, FahjardanInding, Gusmayadi (2015) COMPARISON OF MANNITOL, LACTOSE, AND SUCROSE AS FILLER ORALLY DISINTEGRATING TABLETS DIMENHYDRINAT. INTERNATIONAL SEMINAR ON PHARMACEUTICS 2015. (Submitted)

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Abstract

Dimenhidrinat is one of active substance which can cure the pale. However, not all people can consume the tablet of dimenhidrinat easily. The difficulty to swallow tablet is a problem that happens. Therefore, the presence of ODT was absolutely needed because ODT can conceal the taste of dimenhidrinat (active substance) and help patients who have difficulty to swallow the tablet. The purpose of this research was to find out the usage of comparison for filler substance (manitol, lactose, and sucrose) toward the influence of characteristic’s ODT dimenhidrinat. This tablet was formulated by doing comparison manitol, lactose, sucrose 1:0:0, 0:1:0, 0:0:1, 1:1:0, 0:1:1, 1:0:1, 1:1:1. The tablet is made by direct molding method. From physical test of ODT like hardness test (2,2-4,7kg), friability (0,24-0,81%), weight uniformity (0,1825-0,2202 gram), modified shattered time (31,47-143,33 second), and ingredient uniformity test (95,35-108,18%). Based on Independent test with confidence level 95% (α= 0,05), the quickest shattered time is in formula 7 by comparison of filler substance manitol, lactose, and sucrose (1:1:1) Keyword :Orally Disintegrating Tablet, Filler Substance, Dimenhidrinat

Item Type: Article
Subjects: H Social Sciences > HD Industries. Land use. Labor
Divisions: Fakultas Farmasi dan Sains
Depositing User: Fahjar Prisiska
Date Deposited: 05 Nov 2020 04:16
Last Modified: 05 Nov 2020 04:16
URI: http://repository.uhamka.ac.id/id/eprint/4569

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